![]() ![]() Discard any unused portion after 6 hours. Reconstituted product may be held at a temperature not to exceed 40° C (104° F) for up to 6 hours. See package insert for allowable storage temperatures for kit transport in extreme weather conditions. Attach infusion tubing and begin infusion of the first vial see Rate of Administration. Do Not Shake! Invert or rock vial for a least 60 seconds to mix. If NS is not available, LR or D5W may be used. Using a sterile spike, transfer 200 mL of NS diluent into the glass vial (to the fill line ). The glass vial is marked with a fill line for diluent. DILUTIONĮach kit contains one 5-Gm, 250-mL glass vial of lyophilized hydroxocobalamin, a sterile transfer spike, a sterile vented infusion tubing, a quick-use reference guide, and a package insert. ■ Potential need for dose adjustment in patients with impaired hepatic or renal function has not been studied. No dose adjustments required in the elderly. Safety and effectiveness for use in pediatric patients not established but has been used outside the United States. Based on severity of poisoning and clinical response, a second 5-Gm dose may be administered for a total dose of 10 Gm. Initial dose:ĥ Gm administered by IV infusion over 15 minutes. It covers reconstitution, mixing, infusion rate, common S/S of cyanide poisoning with or without smoke inhalation, incompatibilities, and alternate diluents. Manufacturer provides a quick-use reference guide in carton to facilitate immediate administration. Shelly Rainforth Collins PharmD, BCGP, in Gahart's 2022 Intravenous Medications, 2022 HYDROXOCOBALAMINīaseline assessment required and baseline studies helpful see Precautions and Monitor. ![]()
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